KLRC1

Across TCGA cell cohorts, KLRC1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible KLRC1-associated genes across cancer lineages are PRAMEF33, CCL22, and PRAMEF10. Each is linked with KLRC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLRC1-to-partner and partner-to-KLRC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF33 grouped by KLRC1-low versus KLRC1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLRC1→partner) and Y-score (partner→KLRC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PRAMEF33 →	+0.023	+5.415	<.001	.004	3	2
LUNG_SCLC	CCL22 →	+0.019	+4.256	.005	.002	3	1
LUNG_SCLC	PRAMEF10 →	+0.708	+4.058	<.001	.007	3	1
LUNG_SCLC	PRAMEF17 →	+0.008	+4.058	<.001	.007	3	1
LUNG_SCLC	TECRL →	+0.268	+4.440	<.001	.001	3	1
LUNG_SCLC	OR13C5 →	+0.036	+3.817	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

PRAMEF33 by KLRC1 expression — SKIN

Explore this box plot interactively →