Across TCGA pan-cancer cohorts, KLLN Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KLLN data layer compared with 23 for mass-spec protein.
The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher KLLN Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated KLLN expression acts as an unfavorable survival marker.
KIRP, COAD, and LIHC are the cancer types where KLLN Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.