KLKB1

Across TCGA pan-cancer cohorts, KLKB1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated KLKB1 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher KLKB1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated KLKB1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

COAD, LUAD, and LSCC are the cancer types where KLKB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.880	1.000	.020	42	view →
LUAD	OS	Median	III,IV	0.308	1.000	.001	36	view →
LSCC	DFS	Median	II,III,IV	0.830	1.000	.003	14	view →
GBM	DFS	Median	All	0.269	0.483	.004	11	view →
CCRCC	DFS	Tertile	All	0.916	0.678	.015	11	view →
PDAC	OS	Median	All	0.686	0.954	.010	5	view →
HNSC	OS	Median	All	0.955	1.000	.012	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

KLKB1–COAD (DFS)

Open the COAD breakdown →