KLKB1

Across TCGA patient cohorts, KLKB1 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,274 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible KLKB1-associated proteins across cancer lineages are ARHGAP24_S415, PBLD, and REEP4_S152. Each is linked with KLKB1 in more than 4 cancer types. Because this analysis shows association rather than direction, both KLKB1-to-partner and partner-to-KLKB1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLKB1 versus ARHGAP24_S415 in CCRCC, with a Pearson correlation of 0.39.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (KLKB1→partner) and Y-score (partner→KLKB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ARHGAP24_S415 →	+0.520	+0.924	<.001	<.001	3	5
UCEC	PBLD →	+0.552	+0.651	<.001	.003	3	5
PDAC	REEP4_S152 →	-0.474	-0.486	<.001	<.001	3	4
LUAD	SCLY →	+0.347	+0.628	<.001	.001	3	4
HNSC	SORBS2 →	+0.605	+0.854	<.001	<.001	3	4
LSCC	SORBS2_S259 →	+0.581	+0.269	.003	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,274 associations by consensus.

KLKB1 vs ARHGAP24_S415 — CCRCC

Explore this scatter interactively →