KLKB1

Across TCGA patient cohorts, KLKB1 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLKB1-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and INPP4B. Each is linked with KLKB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLKB1-to-partner and partner-to-KLKB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by KLKB1-low versus KLKB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLKB1→partner) and Y-score (partner→KLKB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.633	+1.720	.005	.025	3	3
UCEC	EGFR_pY1068 →	-0.244	-3.459	.011	.005	3	2
UCEC	INPP4B →	-0.309	-3.700	.012	.001	3	2
UCEC	PCNA →	+0.218	+2.087	.008	.005	3	2
UCEC	PKC-delta_pS664 →	-0.095	-2.321	.039	.033	3	2
UCEC	Rab25 →	-0.355	-1.678	.005	.023	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Caspase-7-cleavedD198 by KLKB1 expression — UCEC

Explore this box plot interactively →