KLKB1

Across TCGA cell cohorts, KLKB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,215 significant associations in total. CNS shows the largest number of these associations.

The most reproducible KLKB1-associated GO terms across cancer lineages are Regulation of alternative mRNA splicing, via spliceosome, miRNA catabolic process, and Fatty acid omega-oxidation. Each is linked with KLKB1 in more than 6 cancer types. Because this analysis shows association rather than direction, both KLKB1-to-partner and partner-to-KLKB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of alternative mRNA splicing, via spliceosome grouped by KLKB1-low versus KLKB1-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLKB1→partner) and Y-score (partner→KLKB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Regulation of alternative mRNA splicing, via spliceosome →	+0.062	+0.181	.006	.002	3	7
OVARY	miRNA catabolic process →	+0.089	+0.130	<.001	.006	3	6
LUNG_SCLC	Fatty acid omega-oxidation →	-0.320	-0.207	<.001	.003	3	6
LARGE_INTESTINE	Cilium or flagellum-dependent cell motility →	-0.056	-0.258	.001	.007	3	6
LARGE_INTESTINE	Cilium-dependent cell motility →	-0.056	-0.258	.001	.007	3	6
LARGE_INTESTINE	Cilium movement involved in cell motility →	-0.067	-0.342	<.001	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,215 associations by consensus.

Regulation of alternative mRNA splicing, via spliceosome by KLKB1 expression — PANCREAS

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