KLKB1

Across TCGA cell cohorts, KLKB1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible KLKB1-associated genes across cancer lineages are MCHR2, LYPD4, and OR8B12. Each is linked with KLKB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLKB1-to-partner and partner-to-KLKB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MCHR2 grouped by KLKB1-low versus KLKB1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLKB1→partner) and Y-score (partner→KLKB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MCHR2 →	+0.017	+3.099	<.001	.002	3	1
LARGE_INTESTINE	LYPD4 →	+0.058	+2.657	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR8B12 →	+0.073	+4.734	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR8A1 →	+0.576	+4.212	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR8B8 →	+0.019	+4.734	.004	.002	3	1
LUNG_NSCLC_LUAD	OR10D3 →	+0.137	+4.544	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

MCHR2 by KLKB1 expression — LARGE_INTESTINE

Explore this box plot interactively →