KLK8

Across TCGA patient cohorts, KLK8 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,597 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible KLK8-associated proteins across cancer lineages are KLK6, SERPINB5, and TRIM29. Each is linked with KLK8 in more than 5 cancer types. Because this analysis shows association rather than direction, both KLK8-to-partner and partner-to-KLK8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLK8 versus KLK6 in LUAD, with a Pearson correlation of 0.62.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK8→partner) and Y-score (partner→KLK8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	KLK6 →	+1.999	+1.984	<.001	.005	3	6
LUAD	SERPINB5 →	+1.215	+0.523	<.001	.007	3	5
OV	TRIM29 →	+0.982	+1.260	<.001	.001	3	5
HNSC	ZNF185 →	+0.558	+1.129	<.001	<.001	3	4
BRCA	KRT17 →	+1.496	+0.863	<.001	<.001	3	4
HNSC	DSC2 →	+0.707	+1.236	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,597 associations by consensus.

KLK8 vs KLK6 — LUAD

Explore this scatter interactively →