KLK8

Across TCGA patient cohorts, KLK8 protein abundance is significantly associated with the RNA expression of many other genes, with 6,926 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible KLK8-associated genes across cancer lineages are KLK11, KLK13, and SKP1. Each is linked with KLK8 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLK8-to-partner and partner-to-KLK8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLK8 versus KLK11 in OV, with a Pearson correlation of 0.53.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK8→partner) and Y-score (partner→KLK8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	KLK11 →	+2.017	+0.898	.004	<.001	3	3
OV	KLK13 →	+1.938	+0.917	.003	.004	3	3
HNSC	SKP1 →	-0.524	-1.045	.004	<.001	3	2
UCEC	STBD1 →	-0.886	-1.163	.003	.004	3	2
UCEC	NRN1 →	-3.425	-1.806	.001	.007	3	2
HNSC	HACL1 →	-0.552	-0.855	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,926 associations by consensus.

KLK8 vs KLK11 — OV

Explore this scatter interactively →