KLK8

Across TCGA patient cohorts, KLK8 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLK8-associated genes across cancer lineages are mTOR, Acetyl-a-Tubulin-Lys40, and mTOR_pS2448. Each is linked with KLK8 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLK8-to-partner and partner-to-KLK8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR grouped by KLK8-low versus KLK8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK8→partner) and Y-score (partner→KLK8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR →	-0.204	-2.222	.002	.011	3	3
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.500	+1.700	.020	.044	3	2
UCEC	mTOR_pS2448 →	-0.159	-2.439	.011	.019	2	3
UCEC	Notch1 →	+0.220	+2.710	<.001	.003	3	2
UCEC	PCNA →	+0.251	+4.000	.006	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.677	+2.479	.007	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

mTOR by KLK8 expression — UCEC

Explore this box plot interactively →