KLK8

Across TCGA cell cohorts, KLK8 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,045 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible KLK8-associated GO terms across cancer lineages are Antimicrobial peptide production, Antimicrobial peptide biosynthetic process, and Antibacterial peptide production. Each is linked with KLK8 in more than 12 cancer types. Because this analysis shows association rather than direction, both KLK8-to-partner and partner-to-KLK8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Antimicrobial peptide production grouped by KLK8-low versus KLK8-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK8→partner) and Y-score (partner→KLK8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Antimicrobial peptide production →	+1.838	+3.790	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Antimicrobial peptide biosynthetic process →	+1.838	+3.790	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Antibacterial peptide production →	+1.838	+3.790	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Antibacterial peptide biosynthetic process →	+1.838	+3.790	<.001	<.001	3	13
LUNG_NSCLC_LUSC	NMDA selective glutamate receptor signaling pathway →	+0.265	+1.614	<.001	.003	3	10
BREAST	Intermediate filament cytoskeleton organization →	+0.182	+3.352	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,045 associations by consensus.

Antimicrobial peptide production by KLK8 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →