KLK8

Across TCGA cell cohorts, KLK8 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLK8-associated genes across cancer lineages are NEXMIF and KCNK16. Each is linked with KLK8 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLK8-to-partner and partner-to-KLK8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NEXMIF grouped by KLK8-low versus KLK8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK8→partner) and Y-score (partner→KLK8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NEXMIF →	+0.319	+4.196	<.001	.002	3	1
SKIN	KCNK16 →	+0.051	+3.930	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

NEXMIF by KLK8 expression — LARGE_INTESTINE

Explore this box plot interactively →