KLK8

Across TCGA cell cohorts, KLK8 mutation is significantly associated with the mutation status of many other genes, with 3,198 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLK8-associated genes across cancer lineages are NOP53, MYO3A, and ASH2L. Each is linked with KLK8 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLK8-to-partner and partner-to-KLK8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NOP53 grouped by KLK8-low versus KLK8-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK8→partner) and Y-score (partner→KLK8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	NOP53 →	+5.502	+5.502	.003	.003	1	3
LARGE_INTESTINE	MYO3A →	+1.974	+3.801	.004	.004	1	3
BLOOD_Lymphoma	ASH2L →	+4.429	+5.247	.005	.005	1	3
LARGE_INTESTINE	USP30 →	+3.459	+3.459	.006	.006	1	3
LARGE_INTESTINE	OSGIN1 →	+4.044	+3.744	.003	.003	1	3
LARGE_INTESTINE	LEFTY2 →	+4.044	+3.744	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,198 associations by consensus.

NOP53 by KLK8 expression — LUNG_SCLC

Explore this box plot interactively →