KLK7

Across TCGA pan-cancer cohorts, KLK7 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated KLK7 data layer compared with 21 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KLK7 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated KLK7 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, PDAC, and LSCC are the cancer types where KLK7 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	1.000	0.344	.009	24	view →
PDAC	DFS	Median	IV	0.199	0.621	.010	14	view →
LSCC	DFS	Median	II,III,IV	0.884	0.537	.018	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

KLK7–HNSC (OS)

Open the HNSC breakdown →