KLK7

Across TCGA patient cohorts, KLK7 mutation is significantly associated with the RNA expression of many other genes, with 138 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLK7-associated genes across cancer lineages are RN7SL666P, RN7SL148P, and MBD3L2. Each is linked with KLK7 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLK7-to-partner and partner-to-KLK7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL666P grouped by KLK7-low versus KLK7-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK7→partner) and Y-score (partner→KLK7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RN7SL666P →	+0.701	+5.212	<.001	.007	3	2
COAD	RN7SL148P →	+0.302	+6.721	.002	<.001	3	2
LUAD	MBD3L2 →	+0.106	+4.444	<.001	.006	3	2
UCEC	TRAJ57 →	+0.646	+2.903	<.001	<.001	3	2
UCEC	CRIP1P3 →	+0.269	+2.130	.003	.006	3	2
SKCM	RN7SKP252 →	+0.213	+4.495	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 138 associations by consensus.

RN7SL666P by KLK7 expression — COAD

Explore this box plot interactively →