KLK7

Across TCGA patient cohorts, KLK7 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLK7-associated genes across cancer lineages are Tuberin_pT1462, VHL, and PRAS40_pT246. Each is linked with KLK7 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLK7-to-partner and partner-to-KLK7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tuberin_pT1462 grouped by KLK7-low versus KLK7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK7→partner) and Y-score (partner→KLK7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Tuberin_pT1462 →	+0.285	+2.179	.018	.034	3	1
UCEC	VHL →	-1.069	-3.000	.002	.036	3	1
UCEC	PRAS40_pT246 →	+0.196	+2.183	.029	.035	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Tuberin_pT1462 by KLK7 expression — UCEC

Explore this box plot interactively →