KLK7

Across TCGA cell cohorts, KLK7 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BONE shows the largest number of these associations.

The most reproducible KLK7-associated genes across cancer lineages are IRGC, GGTLC1, and C1orf105. Each is linked with KLK7 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLK7-to-partner and partner-to-KLK7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IRGC grouped by KLK7-low versus KLK7-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK7→partner) and Y-score (partner→KLK7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	IRGC →	+0.021	+4.000	.006	.008	3	1
BONE	GGTLC1 →	+0.037	+4.169	<.001	.008	3	1
BONE	C1orf105 →	+0.066	+4.307	<.001	.004	3	1
BONE	OR52N1 →	+0.013	+4.307	<.001	.004	3	1
BONE	KRTAP8-1 →	+0.040	+4.169	<.001	.008	3	1
BONE	MAGEB3 →	+0.087	+4.000	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

IRGC by KLK7 expression — BONE

Explore this box plot interactively →