KLK6

Across TCGA pan-cancer cohorts, KLK6 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated KLK6 data layer compared with 20 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KLK6 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated KLK6 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

HNSC, GBM, and PDAC are the cancer types where KLK6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	IV	0.939	0.682	.016	13	view →
GBM	OS	Median	All	0.228	0.544	.007	8	view →
PDAC	DFS	Median	IV	0.203	0.618	.047	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

KLK6–HNSC (OS)

Open the HNSC breakdown →