KLK5

Across TCGA patient cohorts, KLK5 protein abundance is significantly associated with the RNA expression of many other genes, with 4,355 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible KLK5-associated genes across cancer lineages are ACADSB, KLK8, and SLC25A36. Each is linked with KLK5 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLK5-to-partner and partner-to-KLK5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLK5 versus ACADSB in BRCA, with a Pearson correlation of -0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK5→partner) and Y-score (partner→KLK5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ACADSB →	-1.470	-0.970	.001	.002	3	3
HNSC	KLK8 →	+1.455	+1.254	<.001	.002	3	3
LSCC	SLC25A36 →	-1.671	-1.438	.006	.003	3	2
LSCC	KLHL8 →	-0.776	-1.420	.001	.004	3	2
LSCC	PLCD3 →	+1.142	+1.208	.002	.006	3	2
OV	CLHC1 →	-0.963	-1.465	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,355 associations by consensus.

KLK5 vs ACADSB — BRCA

Explore this scatter interactively →