KLK5

Across TCGA cell cohorts, KLK5 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,283 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible KLK5-associated GO terms across cancer lineages are Antimicrobial peptide production, Antimicrobial peptide biosynthetic process, and Antibacterial peptide production. Each is linked with KLK5 in more than 16 cancer types. Because this analysis shows association rather than direction, both KLK5-to-partner and partner-to-KLK5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Antimicrobial peptide production grouped by KLK5-low versus KLK5-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK5→partner) and Y-score (partner→KLK5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Antimicrobial peptide production →	+1.693	+3.970	<.001	<.001	3	17
OESOPHAGUS	Antimicrobial peptide biosynthetic process →	+1.693	+3.970	<.001	<.001	3	17
OESOPHAGUS	Antibacterial peptide production →	+1.693	+3.970	<.001	<.001	3	17
OESOPHAGUS	Antibacterial peptide biosynthetic process →	+1.693	+3.970	<.001	<.001	3	17
BREAST	Cell-substrate junction assembly →	+0.118	+3.757	.003	<.001	3	8
OESOPHAGUS	Protein localization to cell-cell junction →	+0.151	+4.461	.002	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,283 associations by consensus.

Antimicrobial peptide production by KLK5 expression — OESOPHAGUS

Explore this box plot interactively →