KLK5

Across TCGA cell cohorts, KLK5 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible KLK5-associated genes across cancer lineages are OR5H2, OR5H6, and FHL5. Each is linked with KLK5 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLK5-to-partner and partner-to-KLK5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5H2 grouped by KLK5-low versus KLK5-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK5→partner) and Y-score (partner→KLK5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR5H2 →	+0.050	+5.643	<.001	.002	3	1
LUNG_SCLC	OR5H6 →	+0.025	+5.029	<.001	.006	3	1
SKIN	FHL5 →	+0.216	+5.415	<.001	.004	3	1
SKIN	OR2J2 →	+0.013	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

OR5H2 by KLK5 expression — LUNG_SCLC

Explore this box plot interactively →