KLK4

Across TCGA patient cohorts, KLK4 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,231 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible KLK4-associated proteins across cancer lineages are ISLR, CRTAP, and DPYSL3. Each is linked with KLK4 in more than 4 cancer types. Because this analysis shows association rather than direction, both KLK4-to-partner and partner-to-KLK4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLK4 versus ISLR in BRCA, with a Pearson correlation of 0.64.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK4→partner) and Y-score (partner→KLK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ISLR →	+0.851	+1.731	<.001	<.001	3	5
BRCA	CRTAP →	+0.521	+1.284	<.001	<.001	3	5
BRCA	DPYSL3 →	+0.754	+1.583	<.001	<.001	3	5
LUAD	ECM1 →	+0.549	+0.298	<.001	<.001	3	5
UCEC	FKBP7 →	+0.449	+1.231	<.001	<.001	3	5
BRCA	SMCHD1 →	-0.273	-0.843	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,231 associations by consensus.

KLK4 vs ISLR — BRCA

Explore this scatter interactively →