KLK4

Across TCGA patient cohorts, KLK4 mutation is significantly associated with the immune_cell of many other genes, with 13 significant associations in total. COAD shows the largest number of these associations.

The most reproducible KLK4-associated genes across cancer lineages are Erythrocytes, Eosinophils, and mv Endothelial cells. Each is linked with KLK4 in more than 3 cancer types. Because this analysis shows association rather than direction, both KLK4-to-partner and partner-to-KLK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Erythrocytes grouped by KLK4-low versus KLK4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK4→partner) and Y-score (partner→KLK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Erythrocytes →	+0.043	+2.866	.002	.033	3	4
COAD	Eosinophils →	+0.054	+2.686	.021	.010	3	2
SKCM	mv Endothelial cells →	-0.028	-3.526	.004	.002	2	3
COAD	Neurons →	+0.031	+3.040	.031	.018	3	1
COAD	pro B-cells →	+0.183	+2.817	.003	.036	3	1
COAD	Sebocytes →	+0.034	+2.837	.004	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Erythrocytes by KLK4 expression — COAD

Explore this box plot interactively →