KLK4

Across TCGA cell cohorts, KLK4 RNA expression is significantly associated with the RNA expression of many other genes, with 1,906 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLK4-associated genes across cancer lineages are KLK3, AQP7, and HEG1. Each is linked with KLK4 in more than 3 cancer types. Because this analysis shows association rather than direction, both KLK4-to-partner and partner-to-KLK4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLK4 versus KLK3 in LARGE_INTESTINE, with a Pearson correlation of 0.46.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK4→partner) and Y-score (partner→KLK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KLK3 →	+0.913	+1.321	<.001	<.001	3	4
LARGE_INTESTINE	AQP7 →	+0.888	+1.023	.002	.004	3	3
BONE	HEG1 →	-2.422	-0.250	<.001	.003	2	3
BONE	BDNF →	-2.113	-0.214	.002	.007	2	3
LARGE_INTESTINE	SPATA12 →	+0.501	+1.145	<.001	<.001	3	2
SKIN	C12orf75 →	-1.980	-0.360	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,906 associations by consensus.

KLK4 vs KLK3 — LARGE_INTESTINE

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