KLK4

Across TCGA cell cohorts, KLK4 RNA expression is significantly associated with the go_rna of many other GO terms, with 788 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLK4-associated GO terms across cancer lineages are Response to indole-3-methanol, Response to triglyceride, and Epithelial tube branching involved in lung morphogenesis. Each is linked with KLK4 in more than 3 cancer types. Because this analysis shows association rather than direction, both KLK4-to-partner and partner-to-KLK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to indole-3-methanol grouped by KLK4-low versus KLK4-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK4→partner) and Y-score (partner→KLK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Response to indole-3-methanol →	+0.083	+0.285	.004	.008	3	4
UPPER_AERODIGESTIVE_TRACT	Response to triglyceride →	-0.087	-0.217	<.001	.002	3	4
LARGE_INTESTINE	Epithelial tube branching involved in lung morphogenesis →	+0.237	+1.194	<.001	.001	3	4
CNS	D-glucuronate catabolic process to D-xylulose 5-phosphate →	+0.079	+0.059	.001	.008	2	4
UPPER_AERODIGESTIVE_TRACT	Response to thyroid hormone →	+0.128	+0.266	<.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	Cellular response to thyroid hormone stimulus →	+0.099	+0.211	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 788 associations by consensus.

Response to indole-3-methanol by KLK4 expression — OVARY

Explore this box plot interactively →