KLK4

Across TCGA cell cohorts, KLK4 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible KLK4-associated genes across cancer lineages are OR2T4, CT45A6, and ACER1. Each is linked with KLK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLK4-to-partner and partner-to-KLK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2T4 grouped by KLK4-low versus KLK4-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK4→partner) and Y-score (partner→KLK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR2T4 →	+0.033	+5.807	<.001	.001	3	1
OVARY	CT45A6 →	+0.040	+5.196	.003	.005	3	1
LARGE_INTESTINE	ACER1 →	+0.174	+3.823	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

OR2T4 by KLK4 expression — OVARY

Explore this box plot interactively →