KLK3

Across TCGA patient cohorts, KLK3 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,746 significant associations in total. STAD shows the largest number of these associations.

The most reproducible KLK3-associated GO terms across cancer lineages are Branched-chain amino acid metabolic process, Branched-chain amino acid catabolic process, and Purine-containing compound catabolic process. Each is linked with KLK3 in more than 8 cancer types. Because this analysis shows association rather than direction, both KLK3-to-partner and partner-to-KLK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Branched-chain amino acid metabolic process grouped by KLK3-low versus KLK3-high in THCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK3→partner) and Y-score (partner→KLK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	Branched-chain amino acid metabolic process →	+0.044	+0.529	<.001	<.001	3	9
STAD	Branched-chain amino acid catabolic process →	+0.076	+0.185	<.001	<.001	3	9
STAD	Purine-containing compound catabolic process →	+0.067	+0.213	<.001	<.001	3	8
STAD	Golgi lumen acidification →	+0.087	+0.225	<.001	<.001	3	8
STAD	Oxidative phosphorylation →	+0.118	+0.244	<.001	<.001	3	8
ESCA	Vesicle budding from membrane →	+0.062	+0.250	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,746 associations by consensus.

Branched-chain amino acid metabolic process by KLK3 expression — THCA

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