KLK3

Across TCGA patient cohorts, KLK3 mutation is significantly associated with the RNA expression of many other genes, with 1,612 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLK3-associated genes across cancer lineages are FOXRED2, NUDT4B, and STX3. Each is linked with KLK3 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLK3-to-partner and partner-to-KLK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXRED2 grouped by KLK3-low versus KLK3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK3→partner) and Y-score (partner→KLK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXRED2 →	+0.574	+2.338	.003	.003	3	3
LUSC	NUDT4B →	+0.093	+2.608	<.001	.009	3	3
SKCM	STX3 →	+0.640	+2.411	.001	<.001	3	3
CESC	RN7SL447P →	+0.217	+5.201	<.001	.007	3	2
PRAD	PSMA3P1 →	+0.067	+5.420	<.001	.005	3	2
UCEC	TSPY26P →	-0.857	-3.584	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,612 associations by consensus.

FOXRED2 by KLK3 expression — UCEC

Explore this box plot interactively →