KLK3

Across TCGA patient cohorts, KLK3 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLK3-associated genes across cancer lineages are ATM, GSK3-a-b, and MAPK_pT202_Y204. Each is linked with KLK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLK3-to-partner and partner-to-KLK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by KLK3-low versus KLK3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK3→partner) and Y-score (partner→KLK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.550	-2.321	.003	.006	3	2
LUAD	GSK3-a-b →	+0.272	+3.000	.002	.036	3	1
LUAD	MAPK_pT202_Y204 →	-0.440	-3.000	.035	.036	3	1
LUAD	p90 RSK_pT359_S363 →	-0.209	-3.000	.016	.035	3	1
LUAD	AMPK_pT172 →	+0.400	+3.000	.037	.036	3	1
LUAD	S6_pS235_S236 →	-0.468	-3.000	.043	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

ATM by KLK3 expression — UCEC

Explore this box plot interactively →