KLK3

Across TCGA cell cohorts, KLK3 RNA expression is significantly associated with the go_rna of many other GO terms, with 977 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible KLK3-associated GO terms across cancer lineages are Positive regulation of antimicrobial peptide production, Positive regulation of antimicrobial humoral response, and Negative regulation of cholesterol import. Each is linked with KLK3 in more than 11 cancer types. Because this analysis shows association rather than direction, both KLK3-to-partner and partner-to-KLK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of antimicrobial peptide production grouped by KLK3-low versus KLK3-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK3→partner) and Y-score (partner→KLK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Positive regulation of antimicrobial peptide production →	+0.429	+1.051	.004	.007	3	12
PANCREAS	Positive regulation of antimicrobial humoral response →	+0.415	+1.046	.007	.007	3	5
BLOOD_Leukemia	Negative regulation of cholesterol import →	+0.180	+0.291	.008	<.001	3	4
LARGE_INTESTINE	Cardiac cell development →	+0.107	+1.202	<.001	<.001	3	3
LARGE_INTESTINE	Regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway →	-0.133	-0.885	<.001	.002	3	3
BLOOD_Lymphoma	Negative regulation of glycoprotein metabolic process →	+0.081	+0.220	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 977 associations by consensus.

Positive regulation of antimicrobial peptide production by KLK3 expression — PANCREAS

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