KLK2

Across TCGA pan-cancer cohorts, KLK2 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KLK2 data layer compared with 19 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KLK2 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated KLK2 expression acts as an unfavorable survival marker.

HNSC, SCLC, and UCEC are the cancer types where KLK2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.314	0.698	<.001	32	view →
SCLC	OS	Median	All	0.082	0.708	<.001	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LIHC	DFS	Median	All	0.096	0.543	.028	6	view →
SKCM	OS	Median	IV	0.415	0.861	.014	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

KLK2–HNSC (DFS)

Open the HNSC breakdown →