KLK2

Across TCGA patient cohorts, KLK2 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLK2-associated genes across cancer lineages are Cyclin-B1, 14-3-3_beta, and ERK2. Each is linked with KLK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLK2-to-partner and partner-to-KLK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by KLK2-low versus KLK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK2→partner) and Y-score (partner→KLK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.558	+2.000	.027	.032	3	2
UCEC	14-3-3_beta →	-0.121	-2.687	.007	.006	2	2
UCEC	ERK2 →	+0.190	+2.459	.028	.019	2	2
UCEC	p27_pT198 →	+0.109	+2.999	.024	.035	3	1
UCEC	PCNA →	+0.195	+2.000	.045	.032	2	2
UCEC	S6_pS240_S244 →	+0.587	+2.700	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Cyclin-B1 by KLK2 expression — UCEC

Explore this box plot interactively →