KLK2

Across TCGA cell cohorts, KLK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,182 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KLK2-associated GO terms across cancer lineages are SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition, Mitochondrion organization, and Regulation of dendrite development. Each is linked with KLK2 in more than 5 cancer types. Because this analysis shows association rather than direction, both KLK2-to-partner and partner-to-KLK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition grouped by KLK2-low versus KLK2-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK2→partner) and Y-score (partner→KLK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition →	+0.119	+0.865	.001	.003	3	5
BONE	Mitochondrion organization →	+0.049	+0.618	.001	.009	3	5
STOMACH	Regulation of dendrite development →	+0.066	+0.753	.001	.007	2	6
BLOOD_Lymphoma	Regulation of endoplasmic reticulum unfolded protein response →	+0.070	+0.535	<.001	.007	3	5
BLOOD_Lymphoma	Negative regulation of endoplasmic reticulum unfolded protein response →	+0.081	+0.589	<.001	.002	3	5
BLOOD_Lymphoma	Regulation of syncytium formation by plasma membrane fusion →	+0.072	+0.754	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,182 associations by consensus.

SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition by KLK2 expression — BLOOD_Myeloma

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