KLK13

Across TCGA patient cohorts, KLK13 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLK13-associated genes across cancer lineages are Notch1, Annexin-1, and EGFR_pY1068. Each is linked with KLK13 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLK13-to-partner and partner-to-KLK13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by KLK13-low versus KLK13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK13→partner) and Y-score (partner→KLK13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.208	+3.472	<.001	.002	3	2
UCEC	Annexin-1 →	+0.743	+3.341	.001	.005	3	2
UCEC	EGFR_pY1068 →	-0.263	-3.321	.016	.010	3	1
UCEC	A-Raf_pS299 →	-0.177	-3.459	<.001	.005	3	1
UCEC	ERK2 →	+0.167	+2.115	.047	.019	3	1
UCEC	Ku80 →	+0.300	+1.598	.003	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Notch1 by KLK13 expression — UCEC

Explore this box plot interactively →