KLK13

Across TCGA cell cohorts, KLK13 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KLK13-associated genes across cancer lineages are KRTAP6-1, AKAIN1, and OOSP4A. Each is linked with KLK13 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLK13-to-partner and partner-to-KLK13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP6-1 grouped by KLK13-low versus KLK13-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK13→partner) and Y-score (partner→KLK13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	KRTAP6-1 →	+0.060	+4.437	<.001	.004	3	1
SKIN	AKAIN1 →	+0.073	+3.930	<.001	.003	3	1
LUNG_NSCLC_LUAD	OOSP4A →	+0.042	+4.212	<.001	.007	3	1
BLOOD_Leukemia	IFNG →	+0.220	+4.152	<.001	.009	3	1
BLOOD_Leukemia	WFDC12 →	+0.249	+4.874	<.001	.002	3	1
BLOOD_Leukemia	DEFB4A →	+0.123	+5.269	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

KRTAP6-1 by KLK13 expression — SKIN

Explore this box plot interactively →