KLK10

Across TCGA pan-cancer cohorts, KLK10 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KLK10 data layer compared with 27 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher KLK10 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KLK10 expression acts as an unfavorable survival marker.

BLCA, LIHC, and COAD are the cancer types where KLK10 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.185	0.724	<.001	48	view →
LIHC	OS	Median	All	0.127	0.786	<.001	15	view →
COAD	OS	Median	All	0.113	0.806	<.001	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SCLC	OS	Median	II,III,IV	0.152	0.777	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

KLK10–BLCA (OS)

Open the BLCA breakdown →