KLK10

Across TCGA pan-cancer cohorts, KLK10 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of KLK10’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where KLK10 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types KLK10 is over-expressed in tumor, although a few such as OV and LUAD show the opposite, repressed pattern.

PDAC, OV, and LUAD are the cancer types where KLK10 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KLK10 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	All	All	+0.761	<.001	7	view →
OV	All	All	−0.627	.045	2	view →
LUAD	Female	All	−0.619	<.001	2	view →
LSCC	All	II,III,IV	+0.364	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

KLK10–PDAC

Open the PDAC breakdown →