KLK10

Across TCGA patient cohorts, KLK10 mutation is significantly associated with the RNA expression of many other genes, with 1,470 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLK10-associated genes across cancer lineages are RNU6-751P, RN7SL447P, and BRPF1. Each is linked with KLK10 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLK10-to-partner and partner-to-KLK10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-751P grouped by KLK10-low versus KLK10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK10→partner) and Y-score (partner→KLK10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-751P →	+0.110	+3.736	<.001	.009	3	3
SKCM	RN7SL447P →	+0.091	+3.555	<.001	.003	3	3
UCEC	BRPF1 →	+0.377	+3.523	.007	.002	3	2
UCEC	MED27 →	+0.518	+3.064	<.001	<.001	3	2
UCEC	TSC1 →	+0.390	+2.671	.002	.005	3	2
UCEC	ANAPC2 →	+0.407	+3.748	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,470 associations by consensus.

RNU6-751P by KLK10 expression — UCEC

Explore this box plot interactively →