KLK10

Across TCGA patient cohorts, KLK10 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLK10-associated genes across cancer lineages are FoxM1, JNK_pT183_Y185, and Cyclin-B1. Each is linked with KLK10 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLK10-to-partner and partner-to-KLK10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by KLK10-low versus KLK10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK10→partner) and Y-score (partner→KLK10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.287	+2.459	.022	.020	3	2
UCEC	JNK_pT183_Y185 →	-0.208	-2.446	.010	.020	3	2
UCEC	Cyclin-B1 →	+0.639	+2.459	.018	.020	3	2
UCEC	A-Raf_pS299 →	-0.142	-3.000	.014	.036	3	1
UCEC	IGFBP2 →	-0.854	-2.459	.006	.020	3	1
UCEC	MEK1 →	+0.396	+2.459	.025	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

FoxM1 by KLK10 expression — UCEC

Explore this box plot interactively →