Across TCGA pan-cancer cohorts, KLHL9 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated KLHL9 data layer compared with 21 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher KLHL9 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated KLHL9 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, LUAD, and PRAD are the cancer types where KLHL9 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.965	0.623	.010	16	view →
LUAD	OS	Median	II,III,IV	0.171	0.750	.002	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: KLHL9 tumor-vs-normal RNA expression · all KLHL9 data types