KLHL8

Across TCGA pan-cancer cohorts, KLHL8 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated KLHL8 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher KLHL8 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated KLHL8 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

UCEC and LUAD are the cancer types where KLHL8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	All	1.000	0.313	.002	18	view →
LUAD	OS	Quartile	II,III,IV	1.000	0.695	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

KLHL8–UCEC (DFS)

Open the UCEC breakdown →