KLHL8

Across TCGA patient cohorts, KLHL8 protein abundance is significantly associated with the RNA expression of many other genes, with 1,989 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible KLHL8-associated genes across cancer lineages are RCN3, TMEM108, and FLI1. Each is linked with KLHL8 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL8-to-partner and partner-to-KLHL8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLHL8 versus RCN3 in UCEC, with a Pearson correlation of -0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL8→partner) and Y-score (partner→KLHL8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RCN3 →	-1.150	-0.435	<.001	<.001	3	2
LUAD	TMEM108 →	+0.751	+0.415	.003	.008	3	2
HNSC	FLI1 →	-0.789	-1.012	.006	.009	3	2
HNSC	CYSLTR2 →	-0.771	-0.720	.004	.008	3	2
HNSC	RASGRP3 →	-0.729	-0.871	.002	.009	3	2
HNSC	CD8A →	-1.286	-0.932	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,989 associations by consensus.

KLHL8 vs RCN3 — UCEC

Explore this scatter interactively →