KLHL8

Across TCGA patient cohorts, KLHL8 mutation is significantly associated with the RNA expression of many other genes, with 3,269 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL8-associated genes across cancer lineages are HSBP1P2, RN7SKP245, and PFN1P12. Each is linked with KLHL8 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL8-to-partner and partner-to-KLHL8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSBP1P2 grouped by KLHL8-low versus KLHL8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL8→partner) and Y-score (partner→KLHL8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HSBP1P2 →	+0.421	+1.847	<.001	<.001	3	2
CESC	RN7SKP245 →	+0.093	+4.812	<.001	.006	3	2
UCEC	PFN1P12 →	+0.111	+1.558	.007	.002	3	2
CESC	SSXP9 →	+0.101	+4.969	<.001	.004	3	2
BLCA	RNA5SP138 →	+0.274	+7.640	<.001	.009	3	2
SKCM	SLC25A5P9 →	+0.043	+3.137	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,269 associations by consensus.

HSBP1P2 by KLHL8 expression — UCEC

Explore this box plot interactively →