KLHL8

Across TCGA patient cohorts, KLHL8 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL8-associated genes across cancer lineages are PCNA, PDCD4, and ATM. Each is linked with KLHL8 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLHL8-to-partner and partner-to-KLHL8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by KLHL8-low versus KLHL8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL8→partner) and Y-score (partner→KLHL8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.177	+1.440	.018	.024	3	2
UCEC	PDCD4 →	-0.375	-1.440	.021	.024	3	2
UCEC	ATM →	-0.508	-2.459	.001	<.001	3	2
UCEC	Cyclin-B1 →	+0.675	+3.807	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.078	-2.088	.025	.016	3	1
UCEC	eIF4E →	+0.172	+1.736	.018	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

PCNA by KLHL8 expression — UCEC

Explore this box plot interactively →