KLHL8

Across TCGA cell cohorts, KLHL8 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,305 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible KLHL8-associated GO terms across cancer lineages are Negative regulation of gene expression, epigenetic, Nuclear pore organization, and Positive regulation of DNA repair. Each is linked with KLHL8 in more than 14 cancer types. Because this analysis shows association rather than direction, both KLHL8-to-partner and partner-to-KLHL8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of gene expression, epigenetic grouped by KLHL8-low versus KLHL8-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL8→partner) and Y-score (partner→KLHL8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of gene expression, epigenetic →	+0.072	+0.586	.003	.007	3	15
BONE	Nuclear pore organization →	+0.162	+0.679	.001	.002	3	15
SOFT_TISSUE	Positive regulation of DNA repair →	+0.064	+0.851	<.001	<.001	3	14
BONE	Nuclear pore complex assembly →	+0.139	+0.610	.004	.005	3	14
BONE	Nucleosome organization →	+0.125	+0.896	<.001	.001	3	14
LIVER	Regulation of mRNA stability →	+0.056	+0.797	.007	.004	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,305 associations by consensus.

Negative regulation of gene expression, epigenetic by KLHL8 expression — STOMACH

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