KLHL8

Across TCGA cell cohorts, KLHL8 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. URINARY_TRACT shows the largest number of these associations.

The most reproducible KLHL8-associated genes across cancer lineages are OR1L4, SEL1L2, and FHL5. Each is linked with KLHL8 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL8-to-partner and partner-to-KLHL8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L4 grouped by KLHL8-low versus KLHL8-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL8→partner) and Y-score (partner→KLHL8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OR1L4 →	+0.080	+5.087	<.001	.004	3	2
URINARY_TRACT	SEL1L2 →	+0.030	+5.087	<.001	.004	3	1
URINARY_TRACT	FHL5 →	+0.013	+5.087	<.001	.004	3	1
SKIN	IL2 →	+0.039	+5.415	<.001	.004	3	1
SKIN	SMIM9 →	+0.061	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

OR1L4 by KLHL8 expression — URINARY_TRACT

Explore this box plot interactively →