KLHL8

Across TCGA cell cohorts, KLHL8 mutation is significantly associated with the mutation status of many other genes, with 2,377 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLHL8-associated genes across cancer lineages are PCF11, PLXNA4, and ITGB5. Each is linked with KLHL8 in more than 3 cancer types. Because this analysis shows association rather than direction, both KLHL8-to-partner and partner-to-KLHL8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCF11 grouped by KLHL8-low versus KLHL8-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL8→partner) and Y-score (partner→KLHL8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PCF11 →	+4.415	+4.977	.007	.007	1	4
LARGE_INTESTINE	PLXNA4 →	+1.693	+3.506	.008	.008	1	4
OVARY	ITGB5 →	+4.415	+4.977	.007	.007	1	4
OVARY	SLK →	+4.415	+4.977	.007	.007	1	3
OVARY	ELAC2 →	+4.415	+4.977	.007	.007	1	3
OVARY	ADAMTS10 →	+5.415	+5.415	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,377 associations by consensus.

PCF11 by KLHL8 expression — OVARY

Explore this box plot interactively →