KLHL6

Across TCGA patient cohorts, KLHL6 protein abundance is significantly associated with the RNA expression of many other genes, with 10,371 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible KLHL6-associated genes across cancer lineages are LRRK1, GPR25, and DNM1P47. Each is linked with KLHL6 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLHL6-to-partner and partner-to-KLHL6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLHL6 versus LRRK1 in OV, with a Pearson correlation of 0.85.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL6→partner) and Y-score (partner→KLHL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LRRK1 →	+1.486	+0.580	.008	.007	3	3
LSCC	GPR25 →	+0.575	+0.499	<.001	<.001	3	3
UCEC	DNM1P47 →	+0.176	+0.642	.001	.003	3	3
BRCA	CDK3 →	-0.323	-0.426	.009	.008	3	3
PDAC	CSTF1 →	-0.541	-0.837	.006	<.001	3	3
PDAC	FZD3 →	-0.872	-0.620	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,371 associations by consensus.

KLHL6 vs LRRK1 — OV

Explore this scatter interactively →