KLHL6

Across TCGA patient cohorts, KLHL6 mutation is significantly associated with the RNA expression of many other genes, with 3,722 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL6-associated genes across cancer lineages are H2AZ1, PBK, and DEPDC1. Each is linked with KLHL6 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLHL6-to-partner and partner-to-KLHL6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2AZ1 grouped by KLHL6-low versus KLHL6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL6→partner) and Y-score (partner→KLHL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	H2AZ1 →	+0.505	+1.769	<.001	<.001	3	3
UCEC	PBK →	+0.923	+2.203	<.001	<.001	3	3
SKCM	DEPDC1 →	+0.752	+2.254	.002	.001	3	3
UCEC	MCM10 →	+0.588	+2.269	.001	<.001	3	3
GBM	USP9YP2 →	+0.078	+6.189	<.001	.001	3	3
UCEC	BCAS2 →	+0.397	+2.078	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,722 associations by consensus.

H2AZ1 by KLHL6 expression — UCEC

Explore this box plot interactively →