KLHL6

Across TCGA patient cohorts, KLHL6 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL6-associated genes across cancer lineages are ERK2, INPP4B, and C-Raf. Each is linked with KLHL6 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL6-to-partner and partner-to-KLHL6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by KLHL6-low versus KLHL6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL6→partner) and Y-score (partner→KLHL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.140	+2.584	.027	.010	3	2
UCEC	INPP4B →	-0.273	-2.807	.010	.002	3	2
UCEC	C-Raf →	+0.097	+1.502	.039	.027	3	2
SKCM	IGFBP2 →	-0.534	-2.222	.013	.010	3	2
UCEC	EGFR_pY1068 →	-0.198	-1.678	.016	.021	3	1
UCEC	Ku80 →	+0.214	+2.276	.005	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

ERK2 by KLHL6 expression — UCEC

Explore this box plot interactively →